Two-photon Photodynamic Therapy using Trestles femtosecond Ti:Sapphire Laser
Del Mar Photonics customer
Dr. Alex Karotki wrote:
I work on a 2-photon
photodynamic therapy (PDT) project which aims at applying two-photon PDT for
treatment of age related macular degeneration in the eye. The rationale is that
two-photon excitation allows more targeted treatment reducing collateral
damage. It is particularly important for the eye because treatment is done near
fovea which is responsible for central vision. Any damage to healthy tissue may
lead to large decrease of visual acuity. The project involves several Canadian
universities including University of
There are not that many
papers about two-photon PDT. This area of research is relatively new and
untouched. I attached three papers:
1. Application of ex ovo chicken .... - Describes work done in David Cramb's lab.
2. Simultaneous two-photon excitation of Photofrin.... - Describes work done in Brian Wilson's lab.
3. Efficient singlet oxygen generation ... - Gives small description of two-photon PDT.
All three papers contain references of other papers relevant to two-photon PDT. But as I already mentioned, there is not much out there.
|Dr. Alex Karotki
Ontario Cancer Institute
Princess Margaret Hospital
610 University Ave, Rm 7-307
Phone: 416-946-4501 ext. 5916
Dr.Alex Karotki visiting Del Mar Photonics booth during Photonics West 2007.
New product recommended for two-photon photodynamic therapy: Trestles Finesse